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We foresee reposting the pictures at the time we are able determine and filter out images that don't match the information delivered within the drug labels. NDC Codes
The narcotic antagonist, naloxone hydrochloride, might be administered when substantial respiratory depression occurs with promethazine and codeine; any depressant outcomes of promethazine will not be reversed with naloxone. Diazepam might be made use of to regulate convulsions. Avoid analeptics, which may trigger convulsions. Acidosis and electrolyte losses ought to be corrected. A rise in temperature or pulmonary complications may possibly sign the need for establishment of antibiotic therapy.
The subsequent really serious adverse reactions are explained, or described in greater element, in other sections:
Promethazine administered to your pregnant lady in just two weeks of shipping may perhaps inhibit platelet aggregation inside the new child.
Focus–Adverse Response Associations You will find a romantic relationship between rising codeine plasma concentration and rising frequency of dose- relevant opioid adverse reactions which include nausea, vomiting, CNS outcomes, and respiratory depression.
Codeine: A study in rats and rabbits reported no teratogenic result of codeine administered throughout the period of organogenesis in doses starting from 5 to one hundred twenty mg/kg. In the rat, doses in the 120-mg/kg degree, in the toxic assortment for that adult animal, have been connected with a rise in embryo resorption at time of implantation.
Greater threat of seizures. Promethazine HCl Oral Remedy must be employed with caution in people with seizures or who're on other medicines which can also increase the danger of seizures.
Symptoms and indicators of overdosage with Promethazine HCl vary from moderate despair with the central nervous procedure and cardiovascular technique to profound hypotension, respiratory despair, unconsciousness, and sudden death.
two) Spot the combination inside of a sealable bag, empty can, or other container to stop the drug from leaking or breaking out of a rubbish bag, or to dispose of in accordance with nearby point out guidelines and/or laws.
Concomitant administration of Promethazine merchandise with other respiratory depressants has an Affiliation with respiratory melancholy, and sometimes Demise, in pediatric individuals.
The opioid antagonists, naloxone and nalmefene, are particular antidotes for respiratory depression ensuing from opioid overdose. For clinically sizeable respiratory or circulatory depression secondary to codeine overdose, administer an opioid antagonist. An antagonist really should not be administered during the absence of clinically sizeable respiratory despair. Because the duration of opioid reversal is anticipated to get a lot less than the length of action of codeine in Promethazine HCl and Codeine Phosphate Oral Resolution, thoroughly keep an eye on the client till spontaneous respiration is reliably reestablished.
The mix of promethazine hydrochloride and codeine phosphate is contraindicated in pediatric sufferers lower than six yrs of age, due to the fact The mixture could induce lethal respiratory melancholy Within this age inhabitants.
Nevertheless, codeine must be administered only underneath near supervision to patients with a record of drug abuse check here or dependence.